Nonlinear Switching State-Space Models for aCGH Analysis

@inproceedings{Dunn2009NonlinearSS,
  title={Nonlinear Switching State-Space Models for aCGH Analysis},
  author={Jeffrey B Dunn},
  year={2009}
}
DNA copy number aberrations serve as key biological markers for cancer and many other diseases and determining their location has important applications to cancer diagnosis, drug development, and molecular therapy. Analysis of a variety of cancers have revealed that gains present in proto-oncogenes and losses of tumor suppressor genes have serious impacts on growth-limiting functions, cell-death programs, and self-repair processes of cancerous regions. Methods to efficiently and accurately… CONTINUE READING

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