Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses

@article{Mueller2008NonlinearPO,
  title={Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses},
  author={M. Mueller and F. Peters and H. Maurer and U. McCann and G. Ricaurte},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={327},
  pages={38 - 44}
}
  • M. Mueller, F. Peters, +2 authors G. Ricaurte
  • Published 2008
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
    • At certain doses, the psychoactive drug (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) destroys brain serotonin axon terminals. By causing increases in plasma MDMA concentrations that exceed those predicted by the increase in dose, nonlinear pharmacokinetics has the potential to narrow the range between safe and neurotoxic doses of MDMA. The present study sought to determine whether the pharmacokinetics of MDMA in nonhuman primates are nonlinear and, if they are, to identify plasma… CONTINUE READING
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    33 Citations
    Highly Influential Citations
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    Background Citations
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    Methods Citations
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    Results Citations
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    33 Citations
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    Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations.
    • 10
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    Direct Comparison of (±) 3,4-Methylenedioxymethamphetamine (“Ecstasy”) Disposition and Metabolism in Squirrel Monkeys and Humans
    • 28
    3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") : studies on MDMA metabolism and pharmacokinetics in humans and squirrel monkeys
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    Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA) and Its Pharmacodynamic Consequences in the Rat
    • 26
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    Behavioral Effects and Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons
    • 5
    Metabolism and Disposition of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Baboons after Oral Administration: Comparison with Humans Reveals Marked Differences
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    Effects of Dose and Route of Administration on Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine in the Rat
    • 67
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    Endocrine and Neurochemical Effects of 3,4-Methylenedioxymethamphetamine and Its Stereoisomers in Rhesus Monkeys
    • 35
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    Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.
    • 9
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    Studies of (±)-3,4-Methylenedioxymethamphetamine (MDMA) Metabolism and Disposition in Rats and Mice: Relationship to Neuroprotection and Neurotoxicity Profile
    • 24
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