Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses

@article{Mueller2008NonlinearPO,
  title={Nonlinear Pharmacokinetics of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) and Its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA That Develop After Typical Psychoactive Doses},
  author={M. Mueller and F. Peters and H. Maurer and U. McCann and G. Ricaurte},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={327},
  pages={38 - 44}
}
  • M. Mueller, F. Peters, +2 authors G. Ricaurte
  • Published 2008
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • At certain doses, the psychoactive drug (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) destroys brain serotonin axon terminals. By causing increases in plasma MDMA concentrations that exceed those predicted by the increase in dose, nonlinear pharmacokinetics has the potential to narrow the range between safe and neurotoxic doses of MDMA. The present study sought to determine whether the pharmacokinetics of MDMA in nonhuman primates are nonlinear and, if they are, to identify plasma… CONTINUE READING
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