Nonlinear Fitness Consequences of Variation in Expression Level of a Eukaryotic Gene

Abstract

Levels of gene expression show considerable variation in eukaryotes, but no fine-scale maps have been made of the fitness consequences of such variation in controlled genetic backgrounds and environments. To address this, we assayed fitness at many levels of up- and down-regulated expression of a single essential gene, LCB2, involved in sphingolipid… (More)
DOI: 10.1093/molbev/mss248

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