Nonischemic myocardial damage induced by nonocclusive constriction of coronary artery in rats.

@article{Capasso1991NonischemicMD,
  title={Nonischemic myocardial damage induced by nonocclusive constriction of coronary artery in rats.},
  author={Joseph M. Capasso and Peng Li and Piero Anversa},
  journal={The American journal of physiology},
  year={1991},
  volume={260 3 Pt 2},
  pages={H651-61}
}
To determine whether reduction in coronary vessel diameter leads to alterations in cardiac function, coronary perfusion, and tissue integrity, the left coronary artery of rats was narrowed and ventricular hemodynamics measured at 3 and 5 days after surgery. Coronary artery narrowing averaged 62% and end-diastolic pressure was increased, whereas peak systolic pressure, positive change in pressure over time, stroke volume, and total peripheral resistance were decreased. However, this impairment… CONTINUE READING
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