Noninvolvement of CYP2E1 in the (omega-1)-hydroxylation of fatty acids in rat kidney microsomes.

@article{Amet1997NoninvolvementOC,
  title={Noninvolvement of CYP2E1 in the (omega-1)-hydroxylation of fatty acids in rat kidney microsomes.},
  author={Yolande Amet and A Z{\'e}rilli and T Goasduff and Yvonne Dr{\'e}ano and François Berthou},
  journal={Biochemical pharmacology},
  year={1997},
  volume={54 8},
  pages={947-52}
}
Pyrazole, acetone, and ethanol are known to induce cytochrome P450 2E1 (CYP2E1) and fatty acid (omega-1)-hydroxylation in rat liver microsomes. However, the nature of the P450 enzyme involved in this (omega-1)-hydroxylation has not been clearly established in extrahepatic tissues such as kidney. Four enzymatic activities (hydroxylations of chlorzoxazone, 4-nitrophenol, and two fatty acids) were assayed in kidney microsomal preparations of rats treated with CYP2E1 inducers. Per os treatment… CONTINUE READING