Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy.

  title={Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy.},
  author={Adam D. Maxwell and Charles A. Cain and Alexander P. Duryea and Lingqian Yuan and Hitinder S. Gurm and Zhen Xu},
  journal={Ultrasound in medicine & biology},
  volume={35 12},
Clinically available thrombolysis techniques are limited by either slow reperfusion (drugs) or invasiveness (catheters) and carry significant risks of bleeding. In this study, the feasibility of using histotripsy as an efficient and noninvasive thrombolysis technique was investigated. Histotripsy fractionates soft tissue through controlled cavitation using focused, short, high-intensity ultrasound pulses. In vitro blood clots formed from fresh canine blood were treated by histotripsy. The… CONTINUE READING


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