Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced x-ray computed tomography.

@article{Graham2008NoninvasiveQO,
  title={Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced x-ray computed tomography.},
  author={Kevin C. Graham and Nancy L. Ford and Lisa T Mackenzie and Carl O. Postenka and Alan C. Groom and Ian C Macdonald and David W. Holdsworth and Maria Drangova and Ann F. Chambers},
  journal={Investigative radiology},
  year={2008},
  volume={43 2},
  pages={92-9}
}
OBJECTIVES To determine a timepoint after contrast injection that yields equal liver parenchymal and vascular enhancement in micro-computed tomography images. To evaluate the utility of images acquired during this time period for the noninvasive measurement of liver-tumor volume. MATERIALS AND METHODS The imaging timepoint was determined by quantifying the enhancement kinetics of Fenestra VC (0.015 mL/g) in NIH III mice. In respiratory-gated images of tumor bearing mice, the ability to… CONTINUE READING