Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography.

@article{Araujo1991NoninvasiveQO,
  title={Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography.},
  author={Luis I. Araujo and Adriaan A. Lammertsma and Christopher G. Rhodes and Edward O. McFalls and Hidetaka Iida and Eldad Rechavia and Andrea Galassi and Ramesh de Silva and Tyler Jones and Attilio Maseri},
  journal={Circulation},
  year={1991},
  volume={83 3},
  pages={875-85}
}
BACKGROUND Oxygen-15-labeled water is a diffusible, metabolically inert myocardial blood flow tracer with a short half-life (2 minutes) that can be used quantitatively with positron emission tomography (PET). The purpose of this study was to validate a new technique to quantify myocardial blood flow (MBF) in animals and to assess its application in patients. METHODS AND RESULTS The technique involves the administration of 15O-labeled carbon dioxide (C15O2) and rapid dynamic scanning. Arterial… CONTINUE READING

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