Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain.

@article{Emir2011NoninvasiveQO,
  title={Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain.},
  author={Uzay E Emir and Susan K Raatz and Susan E. McPherson and James S. Hodges and Carolyn J. Torkelson and Pierre Tawfik and Tonya White and Melissa Terpstra},
  journal={NMR in biomedicine},
  year={2011},
  volume={24 7},
  pages={
          888-94
        }
}
In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double-edited (1)H MRS at 4 T in the occipital cortex of healthy young [age (mean ± standard deviation) = 20.4 ± 1.4 years] and elderly (age = 76.6 ± 6.1 years) human subjects. Elderly subjects had a lower GSH concentration than younger subjects (p < 0.05). The Asc concentration was not significantly associated with age. Furthermore, the lactate (Lac) concentration was higher in elderly than… CONTINUE READING
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