Noninvasive prenatal diagnosis using ccffDNA in maternal blood: state of the art

@article{BustamanteAragons2010NoninvasivePD,
  title={Noninvasive prenatal diagnosis using ccffDNA in maternal blood: state of the art},
  author={A. Bustamante-Aragon{\'e}s and C. Gonzalez-Gonzalez and M. D. de Alba and E. Ainse and C. Ramos},
  journal={Expert Review of Molecular Diagnostics},
  year={2010},
  volume={10},
  pages={197 - 205}
}
  • A. Bustamante-Aragonés, C. Gonzalez-Gonzalez, +2 authors C. Ramos
  • Published 2010
  • Medicine
  • Expert Review of Molecular Diagnostics
  • Owing to the risk of fetal loss associated with prenatal diagnostic procedures, the last decade has seen great developments in noninvasive prenatal diagnosis (NIPD). The discovery of circulating cell-free fetal DNA (ccffDNA) in maternal plasma has opened new lines of research in alternative technologies that may facilitate safe diagnosis. Because ccffDNA represents only a small fraction of all DNA present in maternal plasma and it is masked by the background of maternal DNA, the scope of NIPD… CONTINUE READING

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