Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing.

  title={Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing.},
  author={Can Liao and Ai-Hua Yin and Chun-fang Peng and Fang Fang Fu and Jie-xia Yang and Ru Li and Yang-Yi Chen and Dong-hong Luo and Yong-ling Zhang and Yan-mei Ou and Jian Li and Jing Wu and Ming-qin Mai and Rui Hou and Frances Camille M Wu and Hongrong Luo and Dongzhi Li and Hai-Liang Liu and Xiao-zhuang Zhang and Kang Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 20},
Massively parallel sequencing (MPS) of cell-free fetal DNA from maternal plasma has revolutionized our ability to perform noninvasive prenatal diagnosis. This approach avoids the risk of fetal loss associated with more invasive diagnostic procedures. The present study developed an effective method for noninvasive prenatal diagnosis of common chromosomal aneuploidies using a benchtop semiconductor sequencing platform (SSP), which relies on the MPS platform but offers advantages over existing… CONTINUE READING
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Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors

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