Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current state of the art

@article{Lo2009NoninvasivePD,
  title={Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current state of the art},
  author={Y. Lo},
  journal={BJOG: An International Journal of Obstetrics & Gynaecology},
  year={2009},
  volume={116}
}
  • Y. Lo
  • Published 2009
  • Biology, Medicine
  • BJOG: An International Journal of Obstetrics & Gynaecology
  • Fetal nucleic acids in maternal plasma have opened up new possibilities for noninvasive prenatal diagnosis of chromosomal aneuploidies. One approach is based on the measurement of the allelic ratio of single nucleotide polymorphisms in the coding region of placental mRNA. Another approach is through the analysis of DNA fragments with different patterns of DNA methylation between fetal and maternal DNA. One other alternative is to enrich the fractional concentration of fetal DNA in maternal… CONTINUE READING
    38 Citations
    Non-invasive prenatal diagnosis of trisomy 21 by dosage ratio of fetal chromosome-specific epigenetic markers in maternal plasma
    • M. Zhang, Tao Li, +5 authors Yuanzhen Zhang
    • Biology, Medicine
    • Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
    • 2011
    • 2
    Noninvasive prenatal diagnosis: 2010.
    • 10
    Non Invasive Prenatal Diagnosis of Aneuploidy: Next Generation Sequencing or Fetal DNA Enrichment?
    • 11
    • Highly Influenced
    • PDF
    Insights into fetal and neonatal development through analysis of cell-free RNA in body fluids.
    • 11

    References

    SHOWING 1-10 OF 57 REFERENCES
    Digital PCR for the molecular detection of fetal chromosomal aneuploidy
    • 273
    • PDF
    Presence of fetal RNA in maternal plasma.
    • 281
    • PDF
    Detection of the placental epigenetic signature of the maspin gene in maternal plasma.
    • S. S. Chim, Y. K. Tong, +6 authors Y. Lo
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 314
    • PDF
    mRNA of placental origin is readily detectable in maternal plasma
    • E. K. Ng, N. Tsui, +6 authors Y. Lo
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 389
    • PDF