Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current state of the art

@article{Lo2009NoninvasivePD,
  title={Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current state of the art},
  author={Yuk Ming Dennis Lo},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2009},
  volume={116}
}
  • Y. Lo
  • Published 1 January 2009
  • Medicine
  • BJOG: An International Journal of Obstetrics & Gynaecology
Fetal nucleic acids in maternal plasma have opened up new possibilities for noninvasive prenatal diagnosis of chromosomal aneuploidies. One approach is based on the measurement of the allelic ratio of single nucleotide polymorphisms in the coding region of placental mRNA. Another approach is through the analysis of DNA fragments with different patterns of DNA methylation between fetal and maternal DNA. One other alternative is to enrich the fractional concentration of fetal DNA in maternal… 
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TLDR
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References

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