Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus


Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, cognitive deterioration and urinary incontinence in elderly individuals. These symptoms can be improved by shunt operation in some but not all patients. Therefore, discovering predictive factors for the surgical outcome is of great clinical importance. We used normalized power variance (NPV) of electroencephalography (EEG) waves, a sensitive measure of the instability of cortical electrical activity, and found significantly higher NPV in beta frequency band at the right fronto-temporo-occipital electrodes (Fp2, T4 and O2) in shunt responders compared to non-responders. By utilizing these differences, we were able to correctly identify responders and non-responders to shunt operation with a positive predictive value of 80% and a negative predictive value of 88%. Our findings indicate that NPV can be useful in noninvasively predicting the clinical outcome of shunt operation in patients with iNPH.

DOI: 10.1038/srep07775

Extracted Key Phrases

4 Figures and Tables

Cite this paper

@inproceedings{Aoki2015NoninvasivePO, title={Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus}, author={Yasunori Aoki and Hiroaki Kazui and Toshihisa Tanaka and Ryouhei Ishii and Tamiki Wada and Shunichiro Ikeda and Masahiro Hata and Leonides Canuet and Themistoklis Katsimichas and Toshimitsu Musha and Haruyasu Matsuzaki and Kaoru Imajo and Hideki Kanemoto and Tetsuhiko Yoshida and Keiko Nomura and Kenji Yoshiyama and Masao Iwase and Masatoshi Takeda}, booktitle={Scientific reports}, year={2015} }