Noninvasive perfusion MRI in Alzheimer's disease: a preliminary report.

  title={Noninvasive perfusion MRI in Alzheimer's disease: a preliminary report.},
  author={T A Sandson and M P O'connor and Reisa A. Sperling and Robert R. Edelman and Steven Warach},
  volume={47 5},
We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parieto-occipital and temporo-occipital to whole slice signal intensity were… CONTINUE READING

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