Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation.

@article{Schule2004NoninvasiveOT,
  title={Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation.},
  author={Georg Schule and Gereon Huttmann and Carsten Framme and Johann Roider and Ralf Brinkmann},
  journal={Journal of biomedical optics},
  year={2004},
  volume={9 1},
  pages={
          173-9
        }
}
In all fundus laser treatments of the eye, the temperature increase is not exactly known. In order to optimize treatments, an online temperature determination is preferable. We investigated a noninvasive optoacoustic method to monitor the fundus temperature during pulsed laser irradiation. When laser pulses are applied to the fundus, thermoelastic pressure waves are emitted, due to thermal expansion of the heated tissue. Using a constant pulse energy, the amplitude of the pressure wave… 
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An optoacoustic method is developed to determine the retinal temperature increase in real time during continuous-wave laser irradiation, and temperature calculations are performed to interpret the results exemplary for transpupillary thermotherapy (TTT).
Non-invasive optoacoustic temperature determination during retinal cw-laser treatments
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Overall the presented optoacoustic method seems feasible for a non-invasive real-time determination of cw-laser induced retinal temperature increases and might serve as a temperature based dosimetry control during retinal laser treatments.
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The extent of retinal laser coagulations depends on the temperature increase at the fundus and the time of irradiation. Due to light scattering within the eye and variable fundus pigmentation the…
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It could be demonstrated that the sizes of the automatically controlled lesions were widely independent of the treatment laser power and the retinal pigmentation, as well as the temperature-dependent pressure amplitudes.
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The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here and should be considered for long time laser treatments.
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TLDR
This work presents a method for determining the optical and thermal properties of layered materials, directly applicable to the retina, using low-energy laser heating and phase-resolved optical coherence tomography (pOCT).
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TLDR
An automatic temperature feedback algorithm is realised to perform uniform sub-visible and visible irradiations with a total irradiation time of 50 ms and showed ophthalmoscopically or angiographically invisible effects for irradiations at 50 °C, despite a wide range of treatment powers.
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TLDR
A noninvasive optoacoustic real-time dosimetry for SRT is developed and proved in vitro and during patient treatment and detects the ophthalmoscopically invisible laser-induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice.
Power-controlled temperature guided retinal laser therapy
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The introduced treatment mode based on an automatic feedback algorithm to reliably generate subvisible and visible irradiations within a constant irradiation time is introduced and can be used for retinal irradiations with adjustable temperature elevations.
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In all laser treatments at the fundus of the eye the temperature increase is unknown. In order to optimize the treatment modalities, a noninvasive online temperature determination is preferable.…
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