Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

  title={Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes},
  author={Laura E. Edgington and Alicia B Berger and Galia Blum and Victoria E Albrow and Margot G Paulick and Neil Lineberry and Matthew S Bogyo},
  journal={Nature Medicine},
Imaging agents that enable direct visualization and quantification of apoptosis in vivo have great potential value for monitoring chemotherapeutic response as well as for early diagnosis and disease monitoring. We describe here the development of fluorescently labeled activity-based probes (ABPs) that covalently label active caspases in vivo. We used these probes to monitor apoptosis in the thymi of mice treated with dexamethasone as well as in tumor-bearing mice treated with the apoptosis… CONTINUE READING


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