Noninvasive optical detection of bone mineral.

@article{Kozloff2007NoninvasiveOD,
  title={Noninvasive optical detection of bone mineral.},
  author={Kenneth M. Kozloff and Ralph Weissleder and Umar Mahmood},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 8},
  pages={1208-16}
}
UNLABELLED FRFP binds to mineral at osteoblastic, osteoclastic, and quiescent surfaces, with accumulation likely modulated by vascular delivery. In vivo visualization and quantification of binding can be accomplished noninvasively in animal models through optical tomographic imaging. INTRODUCTION The development of near-infrared optical markers as reporters of bone metabolism will be useful for early diagnosis of disease. Bisphosphonates bind differentially to osteoblastic and osteoclastic… CONTINUE READING

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