Noninvasive neurostimulation methods for migraine therapy: The available evidence

@article{Schoenen2016NoninvasiveNM,
  title={Noninvasive neurostimulation methods for migraine therapy: The available evidence},
  author={Jean Schoenen and Baschi Roberta and Delphine Magis and Gianluca Coppola},
  journal={Cephalalgia},
  year={2016},
  volume={36},
  pages={1170 - 1180}
}
Background Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate does not exceed 50% on average and the most effective drugs often induce intolerable side effects. During recent years, noninvasive central and peripheral neuromodulation methods have been explored for migraine treatment. Overview A review of the available evidence suggests that noninvasive… 

Tables from this paper

Efficacy and mode of action of external trigeminal neurostimulation in migraine

TLDR
eTNS could chiefly exert its action by modulating the perigenual ACC, which might also be of interest for treating other disorders like fibromyalgia or depression, which remains to be determined if this might be a common mechanism to other peripheral noninvasive neurostimulation methods.

Effectiveness and acceptability of noninvasive brain and nerve stimulation techniques for migraine prophylaxis: a network meta-analysis of randomized controlled trials

TLDR
The high frequency repetitive transcranial magnetic stimulation over C3 yielded the most decreased monthly migraine days among all the interventions, and the high frequency transcutaneous occipital nerve stimulation over Oz yielded a significantly lower drop-out rate than the sham/control groups did.

New strategies for the treatment and prevention of primary headache disorders

TLDR
Promising new approaches for the prevention of primary headache disorders, such as monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor, and small-molecule CGRP receptor antagonists are discussed.

A Short Review of the Non-invasive Transcutaneous Pericranial Electrical Stimulation Techniques and their Application in Headache

TLDR
A variety of neuromodulatory approaches is expanding fastly and has opened new possibilities for treatment of patients suffering from many forms of headache, especially those who have failed traditional pharmacotherapy.

Pathophysiological targets for non-pharmacological treatment of migraine

TLDR
How knowledge of the functional anatomy and physiology of migraine mechanisms holds the key for more specific and effective non-pharmacological treatments is reviewed here.

Neuromodulation for Evaluating the Pathophysiology of Migraine

TLDR
What kinds of paradoxical effects have been described in response to inhibitory and excitatory modulation in patients with episodic and chronic migraine and how neuromodulation can help distinguish patients with chronic migraine from those with medication overuse headache are discussed.

[Neurostimulation of the supraorbital nerve with the Cefaly device - a new method for the treatment of migraine].

  • G. Tabeeva
  • Medicine, Psychology
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
  • 2019
TLDR
Stimulation of the supraorbital nerve with the percutaneous Cefaly device in clinical randomized, controlled studies has demonstrated efficacy in significantly reducing both the frequency of migraine attacks and the total number of days with headache.

Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches

TLDR
These approaches are increasingly seen as a valid treatment option in headache management, especially for patients with medication overuse or contraindications to drug treatment, however, further investigations are needed to consider the effectiveness of these approaches also with respect to the long-term effects.

References

SHOWING 1-10 OF 37 REFERENCES

Migraine prophylaxis by anodal transcranial direct current stimulation, a randomized, placebo-controlled trial.

TLDR
Anodal M1 tDCS may be a safe and useful clinical tool in migraine prophylaxis and the mechanism of action of anodal tDCS on neuromodulation in migraine patients needs further investigation.

Transcranial Direct Current Stimulation (tDCS) of the visual cortex: a proof-of-concept study based on interictal electrophysiological abnormalities in migraine

TLDR
Preventive treatment with anodal tDCS turned out to be beneficial in MoA and proofing the concept that the low preactivation level of the visual cortex in migraine patients can be corrected by an activating neurostimulation.

Transcranial Direct Current Stimulation and Transcutaneous Occipital Nerve Stimulation in Chronic Migraine: A Pilot-Comparison of Therapeutic and Electrophysiological Effects (I3.008)

TLDR
Cathodal visual cortex tDCS and tONS may be interesting options for the non-invasive treatment of CM and their ability to modify nociception and cortical responsivity is compared.

Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study

TLDR
Non-invasive vagus nerve stimulation may be effective as acute treatment for HFEM or CM and may help to reduce medication overuse and medication-associated adverse events.

Pathophysiological targets for non-pharmacological treatment of migraine

TLDR
How knowledge of the functional anatomy and physiology of migraine mechanisms holds the key for more specific and effective non-pharmacological treatments is reviewed here.

Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine

TLDR
The results suggest that the application of cathodal stimulation over the V1 might be an effective prophylactic therapy in migraine, at least with regard to pain control.

High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebo-controlled study

TLDR
Evidence is provided of the efficacy and safety of 10 Hz rTMS in migraine prophylaxis and the primary outcome measures were reduction in headache frequency and severity as assessed by the Visual Analogue Scale (VAS).

Migraine prevention with a supraorbital transcutaneous stimulator: A randomized controlled trial

TLDR
It is proposed that acupuncture can predict the efficacy of STS: if acupuncture is effective, STS will also be effective and worth performing.

Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study

TLDR
The results of this feasibility study offer promise and should prompt further controlled studies of occipital nerve stimulation (ONS) in CM.