Noninvasive monitoring of local drug release using X-ray computed tomography: optimization and in vitro/in vivo validation.

Abstract

In vivo release profiles of drug-loaded biodegradable implants were noninvasively monitored and characterized using X-ray computed tomography (CT). The imaging method was adapted and optimized to quantitatively examine the release of an active agent from a model cylindrical PLGA device (the millirod) into rabbit livers over 48 h. Iohexol, a CT contrast… (More)

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