Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease

@article{Park2006NoninvasiveMO,
  title={Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease},
  author={Jung-eun Park and Kyungmi Lee and Lami Kang and Kon Chu and Seung Up Kim and Manho Kim and J N Roh},
  journal={Journal of Neuroscience Methods},
  year={2006},
  volume={152},
  pages={250-254}
}
A loss of neostriatal neurons is a characteristic of Huntington's disease (HD), and neural tissue transplantation has been performed directly into the striatum. Since the neural stem cells have ability to migrate into the lesion site, we administered immortalized neural stem-like cells (NSC) into the ventricle or via a tail vein following unilateral intrastriatal quinolinic acid lesioning in Sprague-Dawley rats. To identify transplanted NSC, cells were encoded with lac Z and beta-galactosidase… CONTINUE READING
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