Noninvasive mechanical ventilation in patients with obesity hypoventilation syndrome. Long-term outcome and prognostic factors.

@article{Castillejo2015NoninvasiveMV,
  title={Noninvasive mechanical ventilation in patients with obesity hypoventilation syndrome. Long-term outcome and prognostic factors.},
  author={Elena Ojeda Castillejo and Pilar Ramos and Soledad L{\'o}pez Mart{\'i}n and Pilar Resano Barrios and Paula Rodr{\'i}guez and Liliana Mor{\'a}n Caicedo and Jos{\'e} Mar{\'i}a Bell{\'o}n Cano and Jos{\'e} Miguel Rodr{\'i}guez Gonz{\'a}lez-Moro},
  journal={Archivos De Bronconeumologia},
  year={2015},
  volume={51},
  pages={61-68}
}

Figures and Tables from this paper

Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea
TLDR
Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification, and there was a tendency towards lower healthcare resource utilisation in the NIV group.
Survival of Hypercapnic Patients with COPD and Obesity Hypoventilation Syndrome Treated with High Intensity Non Invasive Ventilation in the Daily Routine Care
TLDR
High intensity NIV within routine care is effective in reducing blood CO2 levels in COPD- and in OHS- related chronic respiratory insufficiency.
Cost-effectiveness of positive airway pressure modalities in obesity hypoventilation syndrome with severe obstructive sleep apnoea
TLDR
CPAP is more cost-effective than NIV; therefore, CPAP should be the preferred treatment for patients with OHS with severe OSA, and similar findings were observed in the high and low adherence subgroups.
Sex differences in patients with obesity hypoventilation syndrome: Do they really exist?
TLDR
This study aimed to assess the differences in clinical presentation, comorbidities, adherence to NIV, and prognosis between male and female OHS patients.
Patterns of use, survival and prognostic factors in patients receiving home mechanical ventilation in Western Australia: A single centre historical cohort study
TLDR
The patterns of use, survival and predictors of death in Western Australia are described and motor neurone disorders, sleep apnoea-hypopnea, sleep-related hypoventilation and daytime hypercarbia are identified.
Obesity Hypoventilation Syndrome: New Insights in Diagnosis and Management
TLDR
The diagnosis is conclusively established on basis of a sleep study and arterial blood gases (ABGs), and management requires a holistic approach focusing on weight reduction, lifestyle modification, treatment of comorbidities, and control of the SDB by means of continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) and pulmonary rehabilitation.
Obesity hypoventilation syndrome: a current review
TLDR
Recent advances in the pathophysiology and management of OHS are addressed, the usefulness of determination of venous bicarbonate in screening for OHS, and diagnostic criteria for O HS that eliminate the need for polysomnography are addressed.
Obesity hypoventilation syndrome: current theories of pathogenesis
TLDR
OHS is a complex multiorgan system disease process that appears to be driven by adaptive changes in respiratory physiology and compensatory changes in metabolic processes, both of which are ultimately counter-productive.
Evaluation and Management of Obesity Hypoventilation Syndrome. An Official American Thoracic Society Clinical Practice Guideline
TLDR
Clinicians may use these recommendations, on the basis of the best available evidence, to guide management and improve outcomes among patients with OHS.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome.
TLDR
NIPPV therapy is effective in the treatment of patients with OHS, providing a significant improvement in clinical status and gas exchange, and dyspnea decreased in all but four patients.
The obesity hypoventilation syndrome can be treated with noninvasive mechanical ventilation.
TLDR
NIMV improves the clinical symptoms and the respiratory failure of patients with OHS to a similar degree to that reported for diseases in which its use is completely established, such as kyphoscoliosis.
The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases.
TLDR
Patients with OSAS and chronic respiratory insufficiency had in most cases an associated OHS or COPD, suggesting that OHS is an autonomous disease.
Assessment and management of patients with obesity hypoventilation syndrome.
TLDR
Keeping a high index of suspicion can lead to early recognition and treatment reducing the high burden of morbidity and mortality and related health care expenditure associated with undiagnosed and untreated OHS.
Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial.
TLDR
One month of NIV treatment, although improving sleep and blood gas measurements dramatically, did not change inflammatory, metabolic, and cardiovascular markers.
Clinical Heterogeneity among Patients with Obesity Hypoventilation Syndrome: Therapeutic Implications
TLDR
Nocturnal/diurnal oximetries should be made to assess treatment efficacy in stable OHS patients who fail to achieve good control withCPAP and those controlled with CPAP have better spirometry and a significantly higher apnea-hypopnea index.
...
...