Noninvasive measurement of effective diffusivities in cell immobilization gels through use of near-infrared spectroscopy.

@article{Frazier2001NoninvasiveMO,
  title={Noninvasive measurement of effective diffusivities in cell immobilization gels through use of near-infrared spectroscopy.},
  author={B. L. Frazier and P Larmour and Mark R. Riley},
  journal={Biotechnology and bioengineering},
  year={2001},
  volume={72 3},
  pages={364-8}
}
Encapsulated cell systems provide some advantages over typical suspension cell cultivations as higher cell densities may be obtained; however, the supply of nutrients to the cells often is a limiting factor in productivity. In this study, we describe the development of a new approach to characterize the effective diffusivity of nutrients in immobilized cell materials. Near-infrared spectroscopy is employed to measure nutrient concentrations within a specially designed diffusion chamber that… CONTINUE READING

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