Noninvasive in vivo investigative probes of adaptive mechanisms of neuroendocrine regulation: the paradigm of the hypothalamo-pituitary-gonadal axis in the aging male.


Intermittent signal exchange serves to encode repeated incremental adjustments among central-neural centers and the ensemble of glands comprising any given axis. Interglandular communication proceeds dynamically via pulsatile and basal modes of hormone release, deterministic (dose-responsive) interfaces, and apparently stochastic (randomly varying… (More)


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