Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.

@article{Tjuvajev1996NoninvasiveIO,
  title={Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.},
  author={Juri G. Gelovani Tjuvajev and Ronald L. Finn and Kenichi Watanabe and Revathi Joshi and Takamitsu Oku and J. Foster Kennedy and Bradley Beattie and Jason A Koutcher and Steven Larson and Ronald G. Blasberg},
  journal={Cancer research},
  year={1996},
  volume={56 18},
  pages={
          4087-95
        }
}
Noninvasive imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression is possible with a clinical gamma camera and by single-photon emission tomography (SPECT) using 131I-labeled 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodo-uracil (FIAU). Studies were performed in rats bearing s.c. tumors. Tumors were produced by injection of wild-type RG2 glioma or W256 mammary carcinoma cells into one flank and RG2TK+ glioma or W256TK+ mammary carcinoma cells (that had been… CONTINUE READING

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