Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.

@article{Li2001NoninvasiveDO,
  title={Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.},
  author={B. Li and C. Hartono and R. Ding and V. Sharma and R. Ramaswamy and B. Qian and D. Serur and J. Mouradian and J. Schwartz and M. Suthanthiran},
  journal={The New England journal of medicine},
  year={2001},
  volume={344 13},
  pages={
          947-54
        }
}
BACKGROUND Acute rejection is a serious and frequent complication of renal transplantation, and its diagnosis is contingent on the invasive procedure of allograft biopsy. A noninvasive diagnostic test for rejection could improve the outcome of transplantation. METHODS We obtained 24 urine specimens from 22 renal-allograft recipients with a biopsy-confirmed episode of acute rejection and 127 samples from 63 recipients without evidence of acute rejection. RNA was isolated from the urinary cells… Expand
553 Citations

Paper Mentions

Observational Clinical Trial
The investigators aim to identify urinary exosomal biomarkers that represent the extent of graft fibrosis from deceased donor kidney transplantation. Urinary samples will be collected… Expand
ConditionsKidney Transplant Failure, Renal Fibrosis
InterventionProcedure
Observational Clinical Trial
The purpose of this study is to determine if analysis of urine samples for specific markers can predict transplant rejection in people who have received kidney transplants.  
ConditionsKidney Disease, Kidney Failure, Chronic, Kidney Transplantation
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References

SHOWING 1-10 OF 40 REFERENCES
Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation.
  • 411
  • PDF
Risk factors for chronic rejection in renal allograft recipients.
  • 678
...
1
2
3
4
...