Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

@article{Ward2010NoninvasiveDO,
  title={Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.},
  author={Christopher S Ward and Humsa S. Venkatesh and Myriam M. Chaumeil and Alissa H. Brandes and Mark Vancriekinge and Hagit Dafni and Subramaniam Sukumar and Sarah J. Nelson and Daniel B. Vigneron and John Kurhanewicz and C. David James and Daphne Adele Haas-Kogan and Sabrina M. Ronen},
  journal={Cancer research},
  year={2010},
  volume={70 4},
  pages={1296-305}
}
Numerous mechanism-based anticancer drugs that target the phosphatidylinositol 3-kinase (PI3K) pathway are in clinical trials. However, it remains challenging to assess responses by traditional imaging methods. Here, we show for the first time the efficacy of hyperpolarized (13)C magnetic resonance spectroscopy (MRS) in detecting the effect of PI3K inhibition by monitoring hyperpolarized [1-(13)C]lactate levels produced from hyperpolarized [1-(13)C]pyruvate through lactate dehydrogenase (LDH… CONTINUE READING
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Hyperpolarized 13C MR metabolic imaging: application to brain tumors. Neuro-oncol

  • I Park, P Larson, ML Zeirhut
  • 2010
Highly Influential
3 Excerpts

Aberrant activation of the androgen receptor by NFκ B 2 / p 52 in prostate cancer cells

  • N Nadiminty, W Lou, +6 authors AC Gao
  • Cancer Res
  • 2010

Cellular and in vivo activity of a novel PI3K inhibitor PX-866 for treatment of human glioblastoma. Neurooncol

  • D Koul, R Shen, Y Kondo
  • 2010
1 Excerpt

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