Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum.

Abstract

Previously, we tested the prediction that axonal damage results in decreased axial diffusivity (lambda(parallel)) while demyelination leads to increased radial diffusivity (lambda(perpendicular)). Cuprizone treatment of C57BL/6 mice was a highly reproducible model of CNS white matter demyelination and remyelination affecting the corpus callosum (CC). In the… (More)

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Cite this paper

@article{Sun2006NoninvasiveDO, title={Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum.}, author={Shu-Wei Sun and Hsiao-Fang Liang and Kathryn Trinkaus and Anne H. Cross and Regina C Armstrong and Sheng-Kwei Song}, journal={Magnetic resonance in medicine}, year={2006}, volume={55 2}, pages={302-8} }