Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.

  title={Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.},
  author={Mukesh Harisinghani and Jelle O. Barentsz and Peter F. Hahn and Willem M L L G Deserno and Shahin Tabatabaei and Christine Hulsbergen van de Kaa and Jean J. M. C. H. de la Rosette and Ralph Weissleder},
  journal={The New England journal of medicine},
  volume={348 25},
BACKGROUND Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial-lymphatic fluid transport, could be used in conjunction with high-resolution magnetic resonance imaging (MRI) to reveal small nodal metastases. METHODS Eighty patients with presurgical clinical stage T1, T2, or T3 prostate cancer… CONTINUE READING
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