Noninvasive blood pressure measurement in mice using pulsed Doppler ultrasound.

@article{Reddy2003NoninvasiveBP,
  title={Noninvasive blood pressure measurement in mice using pulsed Doppler ultrasound.},
  author={Anilkumar K. Reddy and George E. Taffet and Sridhar Madala and Lloyd H. Michael and Mark L. Entman and Craig J. Hartley},
  journal={Ultrasound in medicine & biology},
  year={2003},
  volume={29 3},
  pages={379-85}
}
Existing tail-cuff pressure devices for mice use tail flow sensors that measure only systolic and mean pressure. We developed a method to obtain systolic and diastolic pressure in mice using a pulsed Doppler flow velocity sensor and a tail-cuff and validated the method against pressure signals obtained simultaneously from a fluid-filled catheter. The tail-cuff was pressurized to suprasystolic levels to completely occlude the tail artery and then released gradually. The pressure at which the… CONTINUE READING