Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.

@article{Antkowiak2009NoninvasiveAO,
  title={Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.},
  author={Patrick F. Antkowiak and Sarah A. Tersey and Jeffrey D. Carter and Moriel H Vandsburger and Jerry L Nadler and F. H. Epstein and Raghavendra G Mirmira},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 3},
  pages={
          E573-8
        }
}
Loss of beta-cell function in type 1 and type 2 diabetes leads to metabolic dysregulation and inability to maintain normoglycemia. Noninvasive imaging of beta-cell function in vivo would therefore provide a valuable diagnostic and research tool for quantifying progression to diabetes and response to therapeutic intervention. Because manganese (Mn(2+)) is a longitudinal relaxation time (T1)-shortening magnetic resonance imaging (MRI) contrast agent that enters cells such as pancreatic beta-cells… CONTINUE READING
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