Noninvasive Prenatal Genetic Testing: Current and Emerging Ethical, Legal, and Social Issues.

@article{Minear2015NoninvasivePG,
  title={Noninvasive Prenatal Genetic Testing: Current and Emerging Ethical, Legal, and Social Issues.},
  author={Mollie A Minear and Stephanie A. Alessi and Megan A. Allyse and Marsha Michie and Subhashini Chandrasekharan},
  journal={Annual review of genomics and human genetics},
  year={2015},
  volume={16},
  pages={
          369-98
        }
}
Noninvasive prenatal genetic testing (NIPT) for chromosomal aneuploidy involving the analysis of cell-free fetal DNA became commercially available in 2011. The low false-positive rate of NIPT, which reduces unnecessary prenatal invasive diagnostic procedures, has led to broad clinician and patient adoption. We discuss the ethical, legal, and social issues raised by rapid and global dissemination of NIPT. The number of women using NIPT is anticipated to expand, and the number of conditions being… 
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75 Citations
Background Citations
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Methods Citations
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75 Citations

Citation Type

Citation Type

Non-Invasive Prenatal Testing: Review of Ethical, Legal and Social Implications
TLDR
NIPT seems to exacerbate some of the already existing concerns raised by other prenatal tests such as threats to women’s reproductive autonomy and the potential for discrimination and stigmatization of disabled individuals and their families.
Clinical, social and ethical issues associated with non-invasive prenatal testing for aneuploidy
TLDR
NIPT is rapidly becoming a preferred method to screen for chromosomal aneuploidy with the technology now available in over 90 countries and an up-to-date discussion of the key clinical, social and ethical implications associated with this revolutionary technology is provided.
Expanded indications for noninvasive prenatal genetic testing: Implications for the individual and the public
Ethical considerations in prenatal testing: Genomic testing and medical uncertainty.
Ethical, Legal and Social Issues (ELSI) Associated with Non-Invasive Prenatal Testing: Reflections on the Evolution of Prenatal Diagnosis and Procreative Choices
TLDR
The review’s authors highlight the need for an ethically and legally sustainable framework for the implementation of NIPT, which seems poised to become a diagnostic tool, as its scope is likely to broaden in the near future.
Cross-cultural perspectives on decision making regarding noninvasive prenatal testing: A comparative study of Lebanon and Quebec
TLDR
A qualitative study to explore the perceptions, values, and preferences of pregnant women and their partners about NIPT and examine how these values and perceptions influence reproductive autonomy and decision making in relation to NipT in these two different cultural settings, Lebanon and Quebec.
Testing Times: The Social Life of Non-invasive Prenatal Testing
TLDR
The most pressing and often controversial issues which, it is argued, remain unresolved and vital to consider regarding NIPT are outlined.
Governing the futures of non-invasive prenatal testing: An exploration of social acceptability using the Delphi method.
Is preparation a good reason for prenatal genetic testing? Ethical and critical questions.
TLDR
A conceptual model is building a conceptual model that incorporates an empirical understanding of meanings and actions encompassed by prenatal preparation, which can identify (mis)matches between priorities and approaches.
Expanding Use of cfDNA Screening in Pregnancy: Current and Emerging Ethical, Legal, and Social Issues
TLDR
Concerns regarding routinized testing, an unmet and increasing demand for genetic counseling services, social and economic disparities in access, impact on groups living with disabling conditions, and provider liability are addressed.
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