Noninvasive In vivo Analysis of Human Small Intestinal Paracellular Absorption: Regulation by Na+-Glucose Cotransport

  title={Noninvasive In vivo Analysis of Human Small Intestinal Paracellular Absorption: Regulation by Na+-Glucose Cotransport},
  author={J. R. Turner and D. Cohen and R. Mrsny and J. Madara},
  journal={Digestive Diseases and Sciences},
Activation of intestinal Na+–glucose cotransport increases paracellular movement of inert tracers in cultured monolayers, isolated rodent intestinal mucosae, and in rodents in vivo. However, not all studies have demonstrated comparable effects on human intestinal paracellular absorption. We sought to assess the effects of Na+–glucose cotransport on paracellular absorption in human beings using a simple noninvasive assay. Study subjects drank six 200-ml doses of test solution, composed of 0.8% w… Expand
Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria.
Paracellular nutrient absorption is higher in bats than rodents: integrating from intact animals to the molecular level
Cold exposure increases intestinal paracellular permeability to nutrients in the mouse
Intestinal permeability defects: is it time to treat?
  • Matthew A. Odenwald, J. Turner
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2013


Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo.
Paracellular intestinal absorption of glucose, creatinine, and mannitol in normal animals: relation to body size.
Paracellular intestinal transport of six-carbon sugars is negligible in the rat.
Paracellular glucose transport plays a minor role in the unanesthetized dog.
  • J. Lane, E. Whang, +6 authors S. Ashley
  • Chemistry, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 1999
In vivo increase of passive intestinal absorption by cotransporter activation in rat.
Intestinal absorption and excretion of octapeptides composed of D amino acids.
Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model.
Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats.
The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats.
Transmucosal impedance of small intestine: correlation with transport of sugars and amino acids.