Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT.

@article{Kroon2016NoninvasiveIO,
  title={Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT.},
  author={Inge van der Kroon and Karolina Andralojc and Stefanie M A Willekens and Desir{\'e}e Bos and Lieke Joosten and Otto C Boerman and Maarten Brom and Martin Gotthardt},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2016},
  volume={57 5},
  pages={799-804}
}
UNLABELLED Islet transplantation is a promising treatment for type 1 diabetic patients. However, there is acute as well as chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve transplantation outcomes. In this study, islets were visualized after transplantation in a rat model with a dedicated small-animal SPECT scanner by targeting the glucagonlike peptide-1 receptor (GLP-1R), specifically expressed on β-cells, with (111… CONTINUE READING

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