Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice.

@article{Choi2007NoninvasiveTA,
  title={Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice.},
  author={James J. Choi and Mathieu Pernot and Scott A. Small and Elisa E. Konofagou},
  journal={Ultrasound in medicine & biology},
  year={2007},
  volume={33 1},
  pages={95-104}
}
The feasibility of blood-brain barrier (BBB) opening in the hippocampus of wild-type mice using focused ultrasound (FUS) through the intact skull and skin was investigated. Needle hydrophone measurements through ex vivo skulls revealed minimal attenuation ( approximately 18% of the pressure amplitude), a well-focused beam pattern and minute focus displacement through the parietal bone. In experiments in vivo, the brains of three mice were sonicated transcranially. Pulsed ultrasound sonications… CONTINUE READING

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