Nonintegrated viral DNA in rat cells doubly transformed by SV40 and polyoma virus.

@article{Prasad1978NonintegratedVD,
  title={Nonintegrated viral DNA in rat cells doubly transformed by SV40 and polyoma virus.},
  author={I. Prasad and D. Zouzias and C. Basilico},
  journal={Virology},
  year={1978},
  volume={85 1},
  pages={
          328-31
        }
}
Abstract Rat F2408 cells transformed by polyoma virus contain, in addition to integrated viral genomes, a small number (an average of 20–50 copies per cell) of nonintegrated viral DNA molecules. On the other hand, SV40-transformed rat cells contain only integrated viral genomes. SV40-transformed rat cells also differ from the polyoma transformants, in that they grow in soft agar medium at a much slower rate. Cells doubly transformed by polyoma and SV40 can be easily isolated following polyoma… Expand
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