Nonhuman Primates and Translational Research: Progress, Opportunities, and Challenges.

  title={Nonhuman Primates and Translational Research: Progress, Opportunities, and Challenges.},
  author={John D Harding},
  journal={ILAR journal},
  volume={58 2},
  • J. Harding
  • Published 1 December 2017
  • Biology, Medicine
  • ILAR journal
Nonhuman primates (NHPs) are the closest animal models to humans regarding genetics, physiology and behavior. Therefore, NHPs are usually a critical component in translational research projects aimed at developing therapeutics, vaccines, devices or other interventions aimed at preventing, curing or ameliorating human disease. NHPs are often used in conjunction with other animal models, such as rodents, and results obtained using NHPs must often be used as the final criterion for establishing… 

Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment

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Induced Pluripotent Stem Cells from Animal Models: Applications on Translational Research

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Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity.

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Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology

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Animal models of Chagas disease and their translational value to drug development

The application of new technological advances to the field of drug development for Chagas disease has led to the implementation of new and robust/standardized in vivo models that contributed to a better understanding of host/parasite interactions.



Progress and prospects for genetic modification of nonhuman primate models in biomedical research.

This article will focus on the advancement of transgenic NHPs in the past decade, including transgenic technologies and disease modeling, and outline new technologies that may have significant impact in future NHP modeling and conclude with a discussion of the future prospects of the transgenic NHP model.

Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field.

The evidence taken as a whole indicates that nonhuman primates are and will remain an indispensable resource for evaluating the efficacy and safety of novel therapeutic strategies targeting clinically important metabolic diseases, including dyslipidemia and atherosclerosis, type 2 diabetes, hepatic steatosis, steatohepatitis, and hepatic fibrosis, prior to taking these therapies into clinical trials in humans.

Genomic Tools for the Use of Nonhuman Primates in Translational Research.

Genomic resources to aid in stratifying captive populations in regard to genetic and phenotypic characteristics have been developed as an aid to enhancing reproducibility and facilitating more efficient use of animals and should enhance the value of NHPs as preclinical models of human disease.

Genome editing in nonhuman primates: approach to generating human disease models

The findings suggest that there are many possibilities to establish NHP models for human diseases that can mimic human diseases more faithfully than rodent models.

Nonhuman Primate Models and Understanding the Pathogenesis of HIV Infection and AIDS.

Research in NHPs has unique potential for discoveries that will directly lead to new cures for old human and animal diseases, including HIV/AIDS.

Tackling HIV and AIDS: contributions by non-human primate models

NHP studies have advanced the understanding of the crucial events during early infection, and have provided proof-of-concept of antiretroviral drug treatment and prevention strategies that have the potential to make the next generation AIDS-free.

Translational Research in the Nonhuman Primate Model of Tuberculosis.

Infection with Mycobacterium tuberculosis predominantly establishes subclinical latent infection over the lifetime of an individual, with a fraction of infected individuals rapidly progressing to

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Current CVD-related research in NHPs is discussed focusing on selected aspects of CVD for which nonprimate model organism studies have left gaps in the understanding of human disease.

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