Nonhormonal management of menopause-associated vasomotor symptoms: 2015 position statement of The North American Menopause Society

  title={Nonhormonal management of menopause-associated vasomotor symptoms: 2015 position statement of The North American Menopause Society},
  author={Janet S. Carpenter and Margery L. S. Gass and Pauline M. Maki and Katherine M. Newton and JoAnn V. Pinkerton and Maida Taylor and Wulf. H. Utian and P F Schnatz and Andrew M. Kaunitz and Marla Shapiro and Jan Leslie Shifren and Howard N. Hodis and Sheryl A Kingsberg and James H. Liu and Gloria Richard-Davis and Nanette F Santoro and Lynnette Leidy Sievert and Isaac Schiff and Caitlin A. Pike},
Objective:To update and expand The North American Menopause Society's evidence-based position on nonhormonal management of menopause-associated vasomotor symptoms (VMS), previously a portion of the position statement on the management of VMS. Methods:NAMS enlisted clinical and research experts in the field and a reference librarian to identify and review available evidence. Five different electronic search engines were used to cull relevant literature. Using the literature, experts created a… 

Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol)

An umbrella review, supplemented by an additional search for eligible RCTs, aims to synthesize existing evidence on the use of nonpharmacologic, nonherbal interventions to manage bothersome vasomotor symptoms in perimenopausal and postmenopausal women.

Challenges in the Treatment of Vasomotor Symptoms: Update in Non-Hormonal Strategies

The literature review shows that serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptakes inhibitors (SSRIs%), antihypertensives and anticonvulsants, decrease the intensity and frequency of VMS, proving a clinically significant improvement.

Vasomotor menopausal symptoms: is it just hot flashes? Alternative non-hormonal methods of treatment with proven effectiveness (literature review)

The literature data on the role of alternative agents in the correction of vasomotor symptoms of menopause, along with the known efficacy against autonomic complaints for increasing the effectiveness of counseling for older women are presented.

Guideline No. 422a: Menopause: Vasomotor Symptoms, Prescription Therapeutic Agents, Complementary and Alternative Medicine, Nutrition, and Lifestyle.

Fezolinetant in the treatment of vasomotor symptoms associated with menopause

Fezolinetant is the most advanced NK3R antagonist in clinical development for menopause-associated VMS, and results to date have demonstrated rapid and substantial reduction in VMS frequency and severity and associated improvements in health-related quality of life.

Consensus statement for non-hormonal based treatments for menopausal symptoms

  • J. Woyka
  • Medicine, Psychology
    Post reproductive health
  • 2020
Recommendations from NICE 2015 guidelines and other international bodies are incorporated, and much of the most recent information comes from studies involving breast cancer survivors.

Menopause review: Emerging treatments for menopausal symptoms.

  • B. PatelW. Dhillo
  • Medicine, Psychology
    Best practice & research. Clinical obstetrics & gynaecology
  • 2021

Non-hormonal management for menopause

The most effective therapy for treating menopausal symptoms is hormone replacement therapy, however, this is contraindicated for some women and avoided by others, so efforts are continually being made to find alternative and complementary therapies for menopause.

An eHealth approach to treating vasomotor symptoms.

Both group CBT and self-guided CBT are effective in treating VMS, and CBT significantly reduced VMS problem ratings at 9 weeks after randomization compared with usual care, and improvements were maintained at 26 weeks.



Exercise for vasomotor menopausal symptoms.

No evidence is found from randomised controlled trials on whether exercise is an effective treatment relative to other interventions or no intervention in reducing hot flushes and or night sweats in symptomatic women.

Therapeutic decisions for menopause: results of the DAMES project in central Massachusetts

This study documents a relatively heavy burden of symptoms in a relatively healthy population and provides an update on earlier studies in Massachusetts.

S-equol: a potential nonhormonal agent for menopause-related symptom relief.

The preliminary evidence warrants clinicians discussing the potential of S-equol for the alleviation of VMS with patients, and subanalysis of epidemiologic studies suggests that equol producers are more likely to benefit from soyfood consumption than nonproducers with respect to both cardiovascular disease and osteoporosis, although the data are inconsistent.

Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review.

Although individual trials suggest benefits from certain therapies, data are insufficient to support the effectiveness of any complementary and alternative therapy in this review for the management of menopausal symptoms.

A pilot observational study to assess the safety and efficacy of Menoprogen for the management of menopausal symptoms in Chinese women.

The present pilot study found that Menoprogen reduced symptoms associated with perimenopausal and postmenopausal complaints, and the rationale for a randomized, placebo-controlled clinical trial is supported.

Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.

The SSRIs or SNRIs, clonidine, and gabapentin trials provide evidence for efficacy; however, effects are less than for estrogen, few trials have been published and most have methodological deficiencies, generalizability is limited, and adverse effects and cost may restrict use for many women.

Use of complementary and alternative medicine during the menopause transition: longitudinal results from the Study of Women's Health Across the Nation

Although CAM use did vary in some ethnic groups in relation to advancing menopause status, there was no evidence of influence of calendar time on CAM use.

Complementary and Alternative Medicine for Menopausal Symptoms: A Review of Randomized, Controlled Trials

Review of randomized, controlled clinical trials of CAM therapies for menopausal symptoms found black cohosh to be beneficial for treating hot flashes, but these studies were small, of short duration, and far from sufficient to yield definitive conclusions.

Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review

A paucity of appropriate randomized controlled trials means that the effects of flax intervention on post menopause bone mineral density are inconclusive, and flaxseed is currently not indicated for the alleviation of vasomotor symptoms in postmenopausal women.