Nonhomologous end joining and V(D)J recombination require an additional factor.

  title={Nonhomologous end joining and V(D)J recombination require an additional factor.},
  author={Yan Dai and Boris Kysela and Les A. Hanakahi and Kostas Manolis and Enriqueta Riballo and Markus Stumm and Terry O. Harville and Stephen C West and Marjorie A. Oettinger and Penny A Jeggo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 5},
DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also functions to carry out rearrangements at the specialized breaks introduced during V(D)J recombination. Here, we describe a patient with T(-)B(-) severe combined immunodeficiency, whose cells have defects closely resembling those of NHEJ-defective rodent cells. Cells derived from this patient show dramatic radiosensitivity, decreased double-strand break rejoining, and… CONTINUE READING


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Allergy, Asthma and Immunology from Infancy to Adulthood

  • R. I. Schiff, T. O. Harville
  • 1996

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