Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner.

@article{Mosa2009NonhematopoieticCC,
  title={Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner.},
  author={Ahmed R. Mosa and Christian Trumstedt and Emma K Eriksson and Oliver Soehnlein and Frank W H Heuts and Katrin Janik and Andreas Klos and Oliver Dittrich-Breiholz and Michael Kracht and Asa S Hidmark and Hans Wigzell and Martin E Rottenberg},
  journal={Infection and immunity},
  year={2009},
  volume={77 7},
  pages={2908-18}
}
We analyzed the defensive role of the cytosolic innate recognition receptor nucleotide oligomerization domain 1 (NOD1) during infection with Listeria monocytogenes. Mice lacking NOD1 showed increased susceptibility to systemic intraperitoneal and intravenous infection with high or low doses of L. monocytogenes, as measured by the bacterial load and survival. NOD1 also controlled dissemination of L. monocytogenes into the brain. The increased susceptibility to reinfection of NOD1(-/-) mice was… CONTINUE READING

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