Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.

@article{Flutter2010NonhematopoieticAB,
  title={Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.},
  author={Barry Richard Flutter and Noha Edwards and Farnaz Fallah-Arani and Stephen Henderson and J G Chai and Shivajanani Sivakumaran and Sara Ghorashian and Clare Bennett and Gordon J Freeman and Megan Sykes and Ronjon K Chakraverty},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 11},
  pages={3855-68}
}
Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) responses. The major reason for treatment failure is tumor recurrence, which is linked to the eventual loss of functional, host-specific CTLs. In this study, we have explored the role of recipient antigen expression by nonhematopoietic cells in the… CONTINUE READING
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