Nonhalogenated Alkanes Cyclopropane and Butane Affect Neurotransmitter-gated Ion Channel and G-protein–coupled Receptors: Differential Actions on GABAA and Glycine Receptors

@article{Hara2002NonhalogenatedAC,
  title={Nonhalogenated Alkanes Cyclopropane and Butane Affect Neurotransmitter-gated Ion Channel and G-protein–coupled Receptors: Differential Actions on GABAA and Glycine Receptors},
  author={Koji Hara and Edmond I. Eger and Michael J. Laster and R. Adron Harris},
  journal={Anesthesiology},
  year={2002},
  volume={97},
  pages={1512-1520}
}
Background Anesthetic mechanisms of nonhalogenated alkanes cyclopropane and butane are not understood. This study was designed to look at which neurotransmitter receptors are possible targets for these anesthetics. Methods Effects of cyclopropane and butane on eight recombinant receptors expressed in Xenopus oocytes were examined electrophysiologically. To address molecular mechanisms of interaction with glycine and &ggr;-aminobutyric acid type A (GABAA) receptors, cyclopropane was further… 

Anesthetic synergy between two n-alkanes.

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Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and Anesthetics*

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&bgr;3-Containing Gamma-Aminobutyric AcidA Receptors Are Not Major Targets for the Amnesic and Immobilizing Actions of Isoflurane

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