Nongoitrous (type I) amiodarone-associated thyrotoxicosis: evidence of follicular disruption in vitro and in vivo.

@article{Brennan1995NongoitrousI,
  title={Nongoitrous (type I) amiodarone-associated thyrotoxicosis: evidence of follicular disruption in vitro and in vivo.},
  author={Michael D. Brennan and Dana Z Erickson and J. Aidan Carney and Rebecca S. Bahn},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={1995},
  volume={5 3},
  pages={177-83}
}
Treatment with the antiarrhythmic agent amiodarone results in alterations in thyroid hormone metabolism, and can induce either hypothyroidism or hyperthyroidism (amiodarone-associated thyrotoxicosis, AAT). AAT occurs in patients both with and without preexisting goiter. In our study of the nongoitrous variety, the effect in vitro of amiodarone treatment and of concurrent treatment with potential inhibitors on thyroid cells (FRTL-5) was assessed by measuring the release of radiolabeled chromium… CONTINUE READING
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