Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

@article{Kousteni2001NongenotropicSS,
  title={Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity},
  author={Stavroula Kousteni and Teresita M. Bellido and L I Plotkin and C A O'brien and Donald L. Bodenner and Li Hong Han and K. Han and G B DiGregorio and John A. Katzenellenbogen and Benita S Katzenellenbogen and Paula K Roberson and Ronald S. Weinstein and Robert Laurence Jilka and Stavros C Manolagas},
  journal={Cell},
  year={2001},
  volume={104},
  pages={719-730}
}
The relationship of the classical receptors and their transcriptional activity to nongenotropic effects of steroid hormones is unknown. We demonstrate herein a novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis. This action is mediated by the ligand binding domain and eliminated by nuclear targeting of the receptor protein; ERalpha, ERbeta, or AR can transmit it… CONTINUE READING

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