Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

@article{Kousteni2001NongenotropicSS,
  title={Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity},
  author={Stavroula Kousteni and Teresita M Bellido and Lillian Plotkin and Charles A. O'Brien and Donald L. Bodenner and L. Han and Kim Do Han and G B DiGregorio and John A. Katzenellenbogen and Benita S. Katzenellenbogen and Paula K Roberson and Robert S. Weinstein and Robert L. Jilka and Stavros C. Manolagas},
  journal={Cell},
  year={2001},
  volume={104},
  pages={719-730}
}
The relationship of the classical receptors and their transcriptional activity to nongenotropic effects of steroid hormones is unknown. We demonstrate herein a novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis. This action is mediated by the ligand binding domain and eliminated by nuclear targeting of the receptor protein; ERalpha, ERbeta, or AR can transmit it… Expand
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