Nongenomic steroidal modulation of high-affinity serotonin transport.

@article{Chang1999NongenomicSM,
  title={Nongenomic steroidal modulation of high-affinity serotonin transport.},
  author={Allison S. Chang and Shen Ming Chang},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1417 1},
  pages={
          157-66
        }
}
The ability of steroids to modulate high-affinity 5-HT transport was investigated using cell-based models which stably manifest all known properties of this transport system. beta-Estradiol (E2) exhibited noncompetitive, and possibly allosteric, inhibition of both radiolabeled serotonin ([3H]5-HT) transport by, and radiolabeled cocaine congener ([3H]CFT) binding to, this system. Such inhibitory effects were observed within short time courses and unlikely to result from genomic effects normally… CONTINUE READING
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