Nongenomic inhibition of catecholamine secretion by 17beta-estradiol in PC12 cells.

@article{Kim2000NongenomicIO,
  title={Nongenomic inhibition of catecholamine secretion by 17beta-estradiol in PC12 cells.},
  author={Yun-Hee Kim and Eun Mi Hur and T J Park and Kyung Tack Kim},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 6},
  pages={2490-6}
}
We investigated the effects of 17beta-estradiol, an estrogen, on [(3)H]norepinephrine ([(3)H]NE) secretion in PC12 cells. Pretreatment with 17beta-estradiol reduced 70 mM K(+)-induced [(3)H]NE secretion in a concentration-dependent manner with a half-maximal inhibitory concentration (IC(50)) of 2 +/- 1 microM. The 70 mM K(+)-induced cytosolic free Ca(2+) concentration ([Ca(2+)](i)) rise was also reduced when the cells were treated with 17beta-estradiol (IC(50) = 15 +/- 2 microM). Studies with… CONTINUE READING

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