Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon.

@article{Xiao2006NongenomicEO,
  title={Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon.},
  author={Zuoliang Xiao and Weibiao Cao and Piero Biancani and Jos{\'e} Behar},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 5},
  pages={
          G1008-15
        }
}
  • Zuoliang Xiao, W. Cao, J. Behar
  • Published 1 May 2006
  • Biology
  • American journal of physiology. Gastrointestinal and liver physiology
Progesterone (PG) affects muscle cells by genomic mechanisms through nuclear receptors and by nongenomic mechanisms through unidentified pathways. This study aimed to determine the pathways mediating its nongenomic actions. Experiments were performed in dissociated muscle cells from guinea pig colons. Nongenomic actions were defined as those occurring within 10 min of PG exposure. PG blocked the contraction to CCK-8 and NKA (10(-7) M) but did not impair ACh (10(-7) M) and KCl (2.5 x 10(-2) M… 
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