Nongenomic cardiovascular effects of triiodothyronine in euthyroid male volunteers.

  title={Nongenomic cardiovascular effects of triiodothyronine in euthyroid male volunteers.},
  author={Bernhard M. W. Schmidt and Nicole J Martin and Anette C Georgens and Hanns-C Tillmann and Martin Feuring and Michael Christ and Martin Wehling},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={87 4},
T(3) has been shown to exert cardiovascular effects. These effects have not yet been defined with regard to the mode of action (nongenomic vs. genomic) and with regard to an interaction with the adrenergic system in humans. To address these issues we conducted a randomized, double blind, 6-fold cross-over trial in 18 healthy male volunteers. After pretreatment with the beta-agonist dobutamine, the beta-blocking agent esmolol, or placebo (0.9% NaCl), 100 microg T(3) or placebo were injected… CONTINUE READING


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