Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation.


Physiological estrogens, including estrone (E(1)), estradiol (E(2)), and estriol (E(3)), fluctuate with life stage, suggesting specific roles for them in biological and disease processes. We compared their nongenomic signaling and functional actions in GH3/B6/F10 rat pituitary tumor cells. All hormones caused prolactin release at 1 min; the lowest effective… (More)
DOI: 10.1096/fj.08-107672