Nongenomic actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Focus on "L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase".

@article{Bhargava2009NongenomicAO,
  title={Nongenomic actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Focus on "L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase".},
  author={Maneesh Bhargava and Jianxun Lei and David H. Ingbar},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={296 5},
  pages={C977-9}
}
THE MOLECULAR MECHANISMS of the numerous cellular actions of thyroid hormone have been widely studied. The classical mechanism of thyroid hormone action occurs by uptake of L-thyroxine (T4) or 3,5,3 triiodo-L-thyronine (T3) into cells, transport into the cell nucleus, binding with a thyroid receptor (TR), recruitment of coactivators, and regulation of gene transcription via thyroid response elements (TRE). T3 is more potent in these actions than T4. These genomic actions require access of the… CONTINUE READING
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