Nongenetic Determinants of Age at Menarche: A Systematic Review

  title={Nongenetic Determinants of Age at Menarche: A Systematic Review},
  author={Anna Yermachenko and Volodymyr Dvornyk},
  booktitle={BioMed research international},
BACKGROUND The acceleration of pubertal development is an important medical and social problem, as it may result in increased morbidity and mortality in later life. This systematic review summarizes relevant data about nongenetic factors, which contribute to age at menarche (AAM), and suggests those which may be the most important. METHODS The available literature from 1980 till July 2013 was searched using PubMed and Google Scholar databases. Finally, 154 papers were selected for the… CONTINUE READING